Velazquez JJ, LeGraw R, Moghadam F, Tan Y, Kilbourne J, Maggiore JC, Hislop J, Liu S, Cats D, Chuva de Sousa Lopes SM, Plaisier C, Cahan P, Kiani S, Ebrahimkhani MR. Gene Regulatory Network Analysis and Engineering Directs Development and Vascularization of Multilineage Human Liver Organoids. Cell Systems. 2021 Jan 20.
Angrist M, Barrangou R, Baylis F, Brokowski C, Burgio G, Caplan A, Chapman CR, Church GM, Cook-Deegan R, Cwik B, Doudna JA, Evans JH, Greely HT, Hercher L, Hurlbut JB, Hynes RO, Ishii T, Kiani S, Lee LH, Levrier G, Liu DR, Lunshof JE, Macintosh KL, Mathews DJH, Meslin EM, Mills PHR, Montoliu L, Musunuru K, Nicol D, O'Neill H, Qiu R, Ranisch R, Sherkow JS, Soni S, Terry S, Topol E, Williamson R, Zhang F, Davies K. Reactions to the National Academies/Royal Society Report on Heritable Human Genome Editing. CRISPR J. 2020 Oct;3(5):332-349.
Hernandez-Gordillo V*, Casolaro TC*, Ebrahimkhani MR, Kiani S. Multicellular Systems to Translate Somatic Cell Genome Editors to Humans. Current Opinion in Biomedical Engineering 2020. (*co-first authors)
Moghadam F, LeGraw R, Velazquez JJ, Yeo NC, Xu C, Park J, Chavez A, Ebrahimkhani MR, Kiani S. Synthetic immunomodulation with a CRISPR super-repressor in vivo. Nat Cell Biol. 2020 Sep 3;22:1143–1154.
Ferdosi SR, Ewaisha R, Moghadam F, Krishna S, Park JG, Ebrahimkhani MR, Kiani S*, Anderson KS*. Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes. Nat Commun. 2019 Apr 23;10(1):1842. (* co-corresponding authors)
Pineda M, Lear A, Collins JP, Kiani S. Safe CRISPR: Challenges and Possible Solutions. Trends Biotechnol. 2019 Apr;37(4):389-401.
Menn DJ, Pradhan S, Kiani S, Wang X. Fluorescent Guide RNAs Facilitate Development of Layered Pol II-Driven CRISPR Circuits. ACS Synth Biol. 2018 Aug 17;7(8):1929-1936.
Yeo NC, Chavez A*, Lance-Byrne A, Chan Y, Menn D, Milanova D, Kuo CC, Guo X, Sharma S, Tung A, Cecchi RJ, Tuttle M, Pradhan S, Lim ET, Davidsohn N, Ebrahimkhani MR, Collins JJ, Lewis NE, Kiani S*, Church GM*. An enhanced CRISPR repressor for targeted mammalian gene regulation. Nat Methods. 2018 Aug;15(8):611-616. (*co-corresponding authors)
Pineda M, Moghadam F, Ebrahimkhani MR, Kiani S. Engineered CRISPR Systems for Next Generation Gene Therapies. ACS Synth Biol. 2017 Sep 15;6(9):1614-1626.
JE Chapman, D Gillum, S Kiani. Approaches to Reduce CRISPR Off-Target Effects for Safer Genome Editing. Applied Biosafety. 2017 Mar 1;22(1):7-13.
Guye P*, Ebrahimkhani MR*, Kipniss N, Velazquez JJ, Schoenfeld E, Kiani S, Griffith L, Weiss R. Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6. Nat Commun. 2016 Jan 6;7:10243. (*co-first authors)
Kiani S*, Chavez A*, Tuttle M, Hall RN, Chari R, Ter-Ovanesyan D, Qian J, Pruitt BW, Beal J, Vora S, Buchthal J, Kowal EJ, Ebrahimkhani MR, Collins JJ, Weiss R, Church G. Cas9 gRNA engineering for genome editing, activation and repression. Nat Methods. 2015 Sep 7. doi: 10.1038. (*co-first authors)
Chavez A*, Scheiman J*, Vora S*, Pruitt BW, Tuttle M, P R Iyer E, Lin S, Kiani S, Guzman CD, Wiegand DJ, Ter-Ovanesyan D, Braff JL, Davidsohn N, Housden BE, Perrimon N, Weiss R, Aach J, Collins JJ, Church GM. Highly efficient Cas9-mediated transcriptional programming. Nat Methods. 2015 Apr;12(4):326-8. doi: 10.1038. (*co-first authors)
Davidsohn N, Beal J, Kiani S, Adler A, Yaman F, Li Y, Xie Z, Weiss R. Accurate predictions of genetic circuit behavior from part characterization and modular composition. ACS Synth Biol. 2015 Jun 19;4(6):673-81. doi: 10.1021.
Forster F, Chiba K, Schaeffer L, Regalado SG, Lai CS, Gao Q, Kiani S, Farin HF, Clevers H, Cost GC, Urnov FD, Gregory PD, Pachter L, Jaenisch R, Hockemeyer D. Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells. Stem Cell Reports. 2014 Jun 3;2(6):838-52. doi: 10.1016.
Kiani S, Beal J, Ebrahimkhani MR, Huh J, Hall RN, Xie Z, Li Y, Weiss R. CRISPR transcriptional repression devices and layered circuits in mammalian cells. Nat Methods. 2014 Jul;11(7):723-6. doi: 10.1038.
Hockemeyer D, Wang H, Kiani S, Lai CS, Cost GC, Zhang L, Santiago Y, Miller JC, Orlando SJ, Lam S, Vincent AV, Hinkley SJ, Rebar EJ, Gregory PD, Urnov FD, JaenischR. Genetic engineering of human ES and iPS cells using TALE nucleases. Nat Biotechnol. 2011 Jul 7;29(8):731-4. doi: 10.1038.
Kiani S, Valizadeh B, Hormazdi B; Samadi H; Najafi T, Samini M, Dehpour AR. Alteration in male reproductive system in experimental cholestasis: Roles for opioids and nitric oxide overproduction. Eur J Pharmacol. 2009 May 13.
Ebrahimkhani MR, Moezi L, Kiani S, Merat S, Dehpour AR. Opioid receptor blockade improves mesenteric responsiveness in biliary cirrhosis. Dig Dis Sci. 2008 Nov;53(11):3007-11.
Kiani S*, Ebrahimkhani MR*, Shariftabrizi A, Doratotaj B, Payabvash S, Riazi K, Dehghani M, Honar H, Karoon A, Amanlou M, Tavangar SM, Dehpour AR. Opioid system blockade decreases collagenase activity and improves liver injury in a rat model of cholestasis. J Gastroenterol Hepatol. 2007 Mar;22(3):406-13. (* co-first authors)
Naraghi M, Deroee AF, Ebrahimkhani M, Kiani S, Dehpour A. Nitric oxide: a new concept in chronic sinusitis pathogenesis. Am J Otolaryngol. 2007 Sep-Oct;28(5):334-7.
Ebrahimkhani MR, Kiani S, Oakley F, Kendall T, Shariftabrizi A, Tavangar SM, Moezi L, Payabvash S, Karoon A, Hoseininik H, Mann DA, Moore KP, Mani AR, Dehpour AR. Naltrexone, an opioid receptor antagonist, attenuates liver fibrosis in bile duct ligated rats. Gut. 2006 Nov;55(11):1606-16.
Ebrahimkhani MR, Sadeghipour H, Dehghani M, Kiani S, Payabvash S, Riazi K, Honar H, Pasalar P, Mirazi N, Amanlou M, Farsam H, Dehpour AR. Homocysteine alterations in experimental cholestasis and its subsequent cirrhosis. Life Sci. 2005 Apr 8;76(21):2497-512.
Riazi K, Honar H, Homayoun H, Rashidi N, Kiani S, Ebrahimkhani MR, Noorian AR, Ghaffari K, Jannati A, Dehpour AR. The synergistic anticonvulsant effect of agmatine and morphine: possible role of alpha 2-adrenoceptors. Epilepsy Res. 2005 Jun;65(1-2):33-40.
Angrist M, Barrangou R, Baylis F, Brokowski C, Burgio G, Caplan A, Chapman CR, Church GM, Cook-Deegan R, Cwik B, Doudna JA, Evans JH, Greely HT, Hercher L, Hurlbut JB, Hynes RO, Ishii T, Kiani S, Lee LH, Levrier G, Liu DR, Lunshof JE, Macintosh KL, Mathews DJH, Meslin EM, Mills PHR, Montoliu L, Musunuru K, Nicol D, O'Neill H, Qiu R, Ranisch R, Sherkow JS, Soni S, Terry S, Topol E, Williamson R, Zhang F, Davies K. Reactions to the National Academies/Royal Society Report on Heritable Human Genome Editing. CRISPR J. 2020 Oct;3(5):332-349.
Hernandez-Gordillo V*, Casolaro TC*, Ebrahimkhani MR, Kiani S. Multicellular Systems to Translate Somatic Cell Genome Editors to Humans. Current Opinion in Biomedical Engineering 2020. (*co-first authors)
Moghadam F, LeGraw R, Velazquez JJ, Yeo NC, Xu C, Park J, Chavez A, Ebrahimkhani MR, Kiani S. Synthetic immunomodulation with a CRISPR super-repressor in vivo. Nat Cell Biol. 2020 Sep 3;22:1143–1154.
Ferdosi SR, Ewaisha R, Moghadam F, Krishna S, Park JG, Ebrahimkhani MR, Kiani S*, Anderson KS*. Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes. Nat Commun. 2019 Apr 23;10(1):1842. (* co-corresponding authors)
Pineda M, Lear A, Collins JP, Kiani S. Safe CRISPR: Challenges and Possible Solutions. Trends Biotechnol. 2019 Apr;37(4):389-401.
Menn DJ, Pradhan S, Kiani S, Wang X. Fluorescent Guide RNAs Facilitate Development of Layered Pol II-Driven CRISPR Circuits. ACS Synth Biol. 2018 Aug 17;7(8):1929-1936.
Yeo NC, Chavez A*, Lance-Byrne A, Chan Y, Menn D, Milanova D, Kuo CC, Guo X, Sharma S, Tung A, Cecchi RJ, Tuttle M, Pradhan S, Lim ET, Davidsohn N, Ebrahimkhani MR, Collins JJ, Lewis NE, Kiani S*, Church GM*. An enhanced CRISPR repressor for targeted mammalian gene regulation. Nat Methods. 2018 Aug;15(8):611-616. (*co-corresponding authors)
Pineda M, Moghadam F, Ebrahimkhani MR, Kiani S. Engineered CRISPR Systems for Next Generation Gene Therapies. ACS Synth Biol. 2017 Sep 15;6(9):1614-1626.
JE Chapman, D Gillum, S Kiani. Approaches to Reduce CRISPR Off-Target Effects for Safer Genome Editing. Applied Biosafety. 2017 Mar 1;22(1):7-13.
Guye P*, Ebrahimkhani MR*, Kipniss N, Velazquez JJ, Schoenfeld E, Kiani S, Griffith L, Weiss R. Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6. Nat Commun. 2016 Jan 6;7:10243. (*co-first authors)
Kiani S*, Chavez A*, Tuttle M, Hall RN, Chari R, Ter-Ovanesyan D, Qian J, Pruitt BW, Beal J, Vora S, Buchthal J, Kowal EJ, Ebrahimkhani MR, Collins JJ, Weiss R, Church G. Cas9 gRNA engineering for genome editing, activation and repression. Nat Methods. 2015 Sep 7. doi: 10.1038. (*co-first authors)
Chavez A*, Scheiman J*, Vora S*, Pruitt BW, Tuttle M, P R Iyer E, Lin S, Kiani S, Guzman CD, Wiegand DJ, Ter-Ovanesyan D, Braff JL, Davidsohn N, Housden BE, Perrimon N, Weiss R, Aach J, Collins JJ, Church GM. Highly efficient Cas9-mediated transcriptional programming. Nat Methods. 2015 Apr;12(4):326-8. doi: 10.1038. (*co-first authors)
Davidsohn N, Beal J, Kiani S, Adler A, Yaman F, Li Y, Xie Z, Weiss R. Accurate predictions of genetic circuit behavior from part characterization and modular composition. ACS Synth Biol. 2015 Jun 19;4(6):673-81. doi: 10.1021.
Forster F, Chiba K, Schaeffer L, Regalado SG, Lai CS, Gao Q, Kiani S, Farin HF, Clevers H, Cost GC, Urnov FD, Gregory PD, Pachter L, Jaenisch R, Hockemeyer D. Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells. Stem Cell Reports. 2014 Jun 3;2(6):838-52. doi: 10.1016.
Kiani S, Beal J, Ebrahimkhani MR, Huh J, Hall RN, Xie Z, Li Y, Weiss R. CRISPR transcriptional repression devices and layered circuits in mammalian cells. Nat Methods. 2014 Jul;11(7):723-6. doi: 10.1038.
Hockemeyer D, Wang H, Kiani S, Lai CS, Cost GC, Zhang L, Santiago Y, Miller JC, Orlando SJ, Lam S, Vincent AV, Hinkley SJ, Rebar EJ, Gregory PD, Urnov FD, JaenischR. Genetic engineering of human ES and iPS cells using TALE nucleases. Nat Biotechnol. 2011 Jul 7;29(8):731-4. doi: 10.1038.
Kiani S, Valizadeh B, Hormazdi B; Samadi H; Najafi T, Samini M, Dehpour AR. Alteration in male reproductive system in experimental cholestasis: Roles for opioids and nitric oxide overproduction. Eur J Pharmacol. 2009 May 13.
Ebrahimkhani MR, Moezi L, Kiani S, Merat S, Dehpour AR. Opioid receptor blockade improves mesenteric responsiveness in biliary cirrhosis. Dig Dis Sci. 2008 Nov;53(11):3007-11.
Kiani S*, Ebrahimkhani MR*, Shariftabrizi A, Doratotaj B, Payabvash S, Riazi K, Dehghani M, Honar H, Karoon A, Amanlou M, Tavangar SM, Dehpour AR. Opioid system blockade decreases collagenase activity and improves liver injury in a rat model of cholestasis. J Gastroenterol Hepatol. 2007 Mar;22(3):406-13. (* co-first authors)
Naraghi M, Deroee AF, Ebrahimkhani M, Kiani S, Dehpour A. Nitric oxide: a new concept in chronic sinusitis pathogenesis. Am J Otolaryngol. 2007 Sep-Oct;28(5):334-7.
Ebrahimkhani MR, Kiani S, Oakley F, Kendall T, Shariftabrizi A, Tavangar SM, Moezi L, Payabvash S, Karoon A, Hoseininik H, Mann DA, Moore KP, Mani AR, Dehpour AR. Naltrexone, an opioid receptor antagonist, attenuates liver fibrosis in bile duct ligated rats. Gut. 2006 Nov;55(11):1606-16.
Ebrahimkhani MR, Sadeghipour H, Dehghani M, Kiani S, Payabvash S, Riazi K, Honar H, Pasalar P, Mirazi N, Amanlou M, Farsam H, Dehpour AR. Homocysteine alterations in experimental cholestasis and its subsequent cirrhosis. Life Sci. 2005 Apr 8;76(21):2497-512.
Riazi K, Honar H, Homayoun H, Rashidi N, Kiani S, Ebrahimkhani MR, Noorian AR, Ghaffari K, Jannati A, Dehpour AR. The synergistic anticonvulsant effect of agmatine and morphine: possible role of alpha 2-adrenoceptors. Epilepsy Res. 2005 Jun;65(1-2):33-40.